Which of the following is a side effect of Methotrexate?

Methotrexate is a medication commonly used in the treatment of various conditions such as cancer and autoimmune diseases. One of its notable characteristics is that it can produce systemic side effects. This means that it can affect the body as a whole rather than just targeting a specific location.

Common systemic side effects related to Methotrexate include nausea, fatigue, liver toxicity, and suppression of bone marrow function, which can lead to decreased blood cell production. These effects arise because Methotrexate interferes with DNA synthesis and cellular replication, impacting rapidly dividing cells, particularly those in the bone marrow and gastrointestinal tract.

In contrast, the other options do not accurately reflect the common side effects associated with this medication. Increased appetite and improved eyesight are not typical reactions to Methotrexate, and while weight loss can occur due to adverse effects such as nausea or gastrointestinal distress, it is not categorized as a direct side effect of the drug itself. Therefore, identifying systemic side effects as a primary concern aligns with the known pharmacological impact of Methotrexate.