Which of the following inflammatory diseases is associated with HLA-B27 and non-granulomatous uveitis?

The association of HLA-B27 with non-granulomatous uveitis is particularly strong in reactive arthritis. This condition, often triggered by infections in the urogenital or gastrointestinal tract, can result in a triad of arthritis, conjunctivitis, and urethritis. In reactive arthritis, the presence of HLA-B27 is a significant genetic marker that correlates with the disease, as it is found in a substantial portion of affected individuals.

Non-granulomatous uveitis, characterized by a more acute presentation and less inflammation compared to granulomatous types, commonly occurs with reactive arthritis. Other conditions like ulcerative colitis and Crohn's disease are also associated with various eye symptoms and inflammatory responses; however, they are primarily linked with different types of uveitis and do not have the same strong connection with HLA-B27 as reactive arthritis does. Pseudopoditis, though it may present with similar symptoms, is not typically connected to HLA-B27 or non-granulomatous uveitis in the same way as reactive arthritis.