Which of the following drugs is indicated as safe for pregnancy?

Azithromycin is regarded as a safer option during pregnancy compared to the other drugs listed. It is classified as a category B medication by the FDA, which means that studies in pregnant women have not demonstrated a risk to the fetus, and there are no well-controlled studies in pregnant women.

This drug is often indicated for bacterial infections that may occur during pregnancy without posing significant risks. In contrast, fluoroquinolones have been associated with risks such as potential effects on fetal cartilage development; metronidazole is typically advised against in the first trimester due to concerns over teratogenic effects; and aminoglycosides may pose risks of ototoxicity and nephrotoxicity to a developing fetus.

Given the safety profile of azithromycin and the concerns tied to the other medications, it is recognized as the preferred option for treating infections in pregnant individuals.