Which of the following drugs is associated with causing pseudotumor cerebri (PTC)?

Pseudotumor cerebri (PTC), also known as idiopathic intracranial hypertension, is a condition characterized by increased intracranial pressure without an identifiable cause. One of the most notable associations with PTC is the use of certain medications, particularly isotretinoin, which is commonly known by its brand name, Accutane.

Accutane is primarily used for severe acne treatment and has been linked to several side effects, including symptoms of increased intracranial pressure. The mechanism by which isotretinoin causes PTC is not completely understood, but it is thought that it may involve alterations in cerebrospinal fluid dynamics or increased sensitivity of cranial structures.

In the context of other medications listed, azithromycin, cephalosporin, and tetracyclines have not been established as significant contributors to the development of PTC. While they may have their own sets of side effects or interactions, they do not have the same documented association with increased intracranial pressure as Accutane does. Thus, the connection between Accutane and pseudotumor cerebri makes it the correct choice in this scenario.