Which condition is associated with pseudoxanthoma elasticum?

Pseudoxanthoma elasticum is a connective tissue disorder primarily associated with abnormalities in elastic fibers in the skin, eyes, and cardiovascular system. It is most commonly linked to mutations in the ABCC6 gene, which affects how the body handles certain molecules related to elastic tissue. Ehlers-Danlos syndrome, which is listed as one of the options, is a group of connective tissue disorders characterized by hyper-elasticity of the skin, joint hypermobility, and tissue fragility.

Both pseudoxanthoma elasticum and Ehlers-Danlos syndrome involve defects in collagen and elastic tissue, leading to similar signs and symptoms, primarily because they affect the structural integrity of the tissues. The relationship lies in their shared connective tissue manifestations, making Ehlers-Danlos syndrome the most pertinent association among the provided choices.

The other options do not share this direct connective tissue association with pseudoxanthoma elasticum. Sickle-cell disease primarily affects hemoglobin in red blood cells, Paget's disease involves abnormal bone remodeling, and idiopathic reasons signify unknown causes that do not correlate as directly with the conditions affecting elastic fibers as seen in Ehlers-Danlos syndrome.