Which category of drugs is indicated as unsafe during pregnancy?

Aminoglycosides are classified as unsafe during pregnancy due to their potential for causing harm to the developing fetus. This class of antibiotics includes medications such as gentamicin and tobramycin, which can be associated with adverse outcomes, including ototoxicity and nephrotoxicity in the unborn child. The risk of these serious side effects makes it crucial to avoid the use of aminoglycosides unless absolutely necessary and when the benefits outweigh the risks.

In contrast, the other drug categories—penicillins, cephalosporins, and azithromycin—are generally considered safer options during pregnancy, with many being prescribed when necessary to treat infections.