According to the ABCDE evaluation for malignant melanoma, what does "C" stand for?

In the ABCDE evaluation for malignant melanoma, "C" stands for color difference. This refers to the observation that a mole or skin lesion may have multiple colors present, which can include shades of brown, black, tan, red, white, or blue. The presence of more than one color, especially if it appears unevenly distributed within the lesion, is an important factor in assessing the risk of melanoma. When examining moles, a lack of uniformity in color can signal potential malignancy, prompting further investigation. The focus is on the variation in color which is associated with increased risk.